American actor Eric Dane, best known for his roles on Grey’s Anatomy and Euphoria, has died at the age of 53 after a year‑long battle with amyotrophic lateral sclerosis (ALS), his family confirmed on Friday.
Dane passed away on Thursday afternoon, February 19, 2026, after courageously facing the progressive neurodegenerative disease, often called Lou Gehrig’s disease, which affects nerve cells controlling muscles. In a statement shared with media outlets, his family said he spent his final days surrounded by close friends, his devoted wife Rebecca Gayheart, and their two daughters, Billie and Georgia, who were “the center of his world.”
The actor rose to fame for his portrayal of Dr. Mark “McSteamy” Sloan on Grey’s Anatomy, a role that made him a household name and earned him widespread recognition. He also starred as Cal Jacobs on HBO’s hit series Euphoria, and appeared in films such as Marley & Me, Valentine’s Day and Burlesque.
Dane publicly revealed his ALS diagnosis in April 2025, describing the onset of symptoms as a life‑altering moment. During his illness, he became a vocal advocate for ALS awareness and research, often speaking about his experiences and supporting efforts to improve conditions and funding for others facing the disease.
Throughout his public fight, Dane received widespread support from fans and Hollywood colleagues. Tributes have poured in following the news of his death, with actors, creators and fans remembering him not only for his memorable performances but also for his courage and resilience in the face of a devastating illness.
ALS is a terminal condition that progressively weakens muscles and affects physical function. Patients often lose the ability to walk, speak, eat and eventually breathe independently. The cause of ALS remains largely unknown, and there is currently no cure.
Dane’s family requested privacy as they navigate this difficult time, noting that he “will be deeply missed and lovingly remembered always.”